Semax Peptide: Exploring its Potential in Cognitive Enhancement and Neuroprotection


Semax is gaining attention in neurological research due to its potential effects on brain function [1]. Researchers are also keenly studying its role in stroke recovery within experimental models, sparking curiosity about what more can be unearthed from this fascinating peptide.

Effects of Semax in Clinical Trials

Originating from Russia, Semax is a research peptide that’s been under investigation for its potential neurological effects. Semax is a seven-amino acid peptide derived from the ACTH hormone [1].

A distinguishing characteristic of Semax lies in its molecular structure – it features an unusual N-terminal Pro-Gly-Pro sequence. Its stability against enzymatic degradation makes it more intriguing to researchers [3].

Semax in Neurological Research

The compound’s unique structure is believed to play a key role in its neuroprotective properties. Studies suggest that Semax could potentially help neurons stay alive in situations of oxidative strain and oxygen deprivation by boosting BDNF expression. However, these findings have only been observed under controlled laboratory conditions [1].

Besides this protective capacity, there’s growing curiosity about how Semax could potentially modulate neurotransmitter systems. In rodent models, researchers found that Semax influenced serotonin and dopamine levels – crucial components for mood regulation and cognitive function respectively. It must be stressed though that such outcomes were limited to experimental settings [2].

The Role of Semax in Stroke Research

One fascinating area of exploration is the potential role of Semax in preventing ischemic stroke [4].

Semax has been studied for its neuroprotective properties that might aid recovery post-stroke. Researchers noted improved brain activity and decreased symptoms following a simulated stroke event in rodents treated with Semax [4].

This peptide seems to stimulate certain processes within the brain which can potentially help fix damage caused by strokes. It appears to increase cerebral blood flow and boost neuron survival. The peptide’s antioxidant properties may also play a part in reducing oxidative stress commonly associated with strokes [4].

Impact on Immune and Vascular Systems

Semax affects the immune system and gene expression in a number of ways. It increases both the number and the mobility of immune cells. It can improve the body’s ability to fight off infection and disease [6].

Semax can also impact the gene expression of the vascular system. It improves blood flow and circulation [6]. 

Peptide Comparison: Semax vs. Selank

When comparing peptides, it’s vital to understand their unique characteristics and potential research applications. In this case, we’ll examine two well-known subjects of peptide research: Semax and Selank.

Semax is a synthetic heptapeptide, meaning it consists of seven amino acids linked in a specific sequence. Researchers have been studying its possible effects on neurological function as part of ongoing experimental trials [1].

In contrast, Selank is an anxiolytic peptide developed by the Institute of Molecular Genetics in Russia. This means that while both are peptides with potentially significant implications for neurobiology research, they target different areas within this broad field [4].

The structural differences between these two peptides also lead to varied approaches when studying them. For example, the use cases for Semax often revolve around cognitive enhancement studies due to its supposed nootropic properties, whereas researchers study Selank more from the perspective of anxiety reduction experiments because of its suspected calming effects [4,5].

Future Directions in Semax Research

One possible direction is the exploration of Semax’s potential impact on neuroplasticity. Studies have shown promising results regarding its ability to promote neuronal growth and development, but more comprehensive investigations are needed. This could open up new avenues in understanding brain health and recovery [8].

A second area ripe for investigation involves a deeper look into Semax’s role in stroke recovery research. Preliminary studies suggest it may aid neural regeneration post-stroke, an avenue worth exploring further [4].

Lastly, comparative analyses between peptides like Selank and Semax hold great promise for discerning their unique properties and applications in research on the body. Such comparisons can provide valuable insights that fuel innovation within peptide science [4,5].

FAQs in Relation to Semax

Semax is used for its potential effects on brain function, including the modulation of brain-derived neurotrophic factor (BDNF) and gene expression. It has shown promise in treating circulatory disorders, ischemic stroke, optic nerve disease, and traumatic brain injury, based on clinical and electrophysiological studies [7]. 

Semax is legal in most countries. However, it is important to check the laws in your country before purchasing or using Semax.

Semax is available as a nasal spray or injectable solution. It is typically taken once or twice a day [1].

Most people start to see results from Semax within a few weeks of use. However, it may take up to 12 weeks to see the full effects of Semax.


Semax is a unique research peptide and cognitive enhancer. This compound’s ability to positively impact neurological properties, and improve cognitive function. Its impact on stroke research makes it a promising compound for researchers [1]. 

For more information on Semax or other peptides, visit out database of knowledgeable doctors.

Scientific Research References:

1. Koroleva, S.V., Myasoedov, N.F. Semax as a Universal Drug for Therapy and Research. Biol Bull Russ Acad Sci 45, 589–600 (2018). 

2. Sharonova, I. N., Bukanova, Y. V., Myasoedov, N. F., & Skrebitskii, V. G. (2018). Modulation of gaba-and glycine-activated ionic currents with Semax in isolated cerebral neurons. Bulletin of Experimental Biology and Medicine, 164, 612-616.

3. Dmitrieva, V. G., Povarova, O. V., Skvortsova, V. I., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2010). Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cellular and molecular neurobiology, 30, 71-79.

4. Nadorova, A. V., Kolik, L. G., Klodt, P. M., Narkevich, V. B., Naplyokova, P. L., Kozlovskaya, M. M., & Kudrin, V. S. (2014). The relationship between the anxiolytic action of selank and the level of serotonin in brain structures during the modeling of alcohol abstinence in rats. Neurochemical journal, 8, 115-120.

5. Liapina, L. A., Pastorova, V. E., TIu, O., Samonina, G. E., Ashmarin, I. P., & Miasoedov, N. F. (2006). Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application. Izvestiia Akademii nauk. Seriia Biologicheskaia, (2), 193-203.

6. Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC genomics, 15, 1-12.

7. Shadrina, M., Kolomin, T., Agapova, T., Agniullin, Y., Shram, S., Slominsky, P., … & Myasoedov, N. (2010). Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. Journal of molecular neuroscience41, 30-35.

8. Glazova, N. Y., Manchenko, D. M., Volodina, M. A., Merchieva, S. A., Andreeva, L. A., Kudrin, V. S., … & Levitskaya, N. G. (2021). Semax, synthetic ACTH (4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides86, 102114.

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