Selank Peptide: Exploring its Potential in Anxiety and Cognitive Enhancement


Selank, a peptide of considerable scientific intrigue, exists at the forefront of research regarding biologically active compounds. Selank emerges as a notable subject of study, poised to expand our understanding of its mechanisms and potential applications.

This small molecule carries with it a significant weight of scientific curiosity, both in its origins and the intricate questions it sparks. Read on to understand Selank and what it offers for science and research.

Understanding Selank

Selank is a synthetic peptide, closely related to the immune-regulating molecule tuftsin. This connection hints at its significant potential in scientific research [1].

The structure of Selank mirrors that of tuftsin but with additional alterations for enhanced potency and stability [1]. These tweaks allow it to outperform natural peptides in experimental settings, making it an attractive subject for study.

Selank’s synthesis involves combining naturally occurring amino acids into a specific sequence, much like stringing together letters to form words. But instead of creating sentences, this process produces complex molecules capable of interacting with biological systems in novel ways [2].

One area where Selank has drawn interest is neuroscience. Its ability to bind certain receptors within the brain suggests potential applications in cognitive studies source [2].

  • This binding activity may influence neuronal communication,
  • Potentially altering patterns associated with stress or anxiety,
  • All while maintaining high bioavailability and low toxicity profiles according to preliminary studies source [2].

While these findings are intriguing, they stem from preclinical investigations using non-human subjects or isolated cell cultures; thus far no clinical trials have confirmed these effects on mammals.

The Origin and History of Selank

Selank peptide, a small amino acid chain with big potential, has its roots firmly planted in Russian scientific research. It was first synthesized in the late 1990s by the Institute of Molecular Genetics at the Russian Academy of Sciences [3].

This remarkable peptide is derived from another naturally occurring substance called Tuftsin. Tuftsin itself plays an essential role in our immune system’s functioning [2].

Researchers were intrigued by Tuftsin’s properties and began exploring how to use it for other purposes. That led them to create Selank — a longer version that combined tuftsin with additional amino acids.

The Journey Forward

Selank has come far since its inception two decades ago. Researchers have extensively studied this unique molecule both in preclinical trials as well as human studies conducted within strict ethical guidelines laid down by international regulatory bodies like The World Medical Association (WMA).

However, despite being relatively young compared to many established pharmaceuticals, Selank’s journey isn’t over. Scientists continue to explore its potential in various fields.

Potential Mechanisms of Action

When it comes to the Selank peptide, researchers ask, how does this molecule interact with the biological systems? While full answers remain elusive, here is what science is showing.

Everything starts in the brain. Selank seems to play an important role in regulating neuropeptides, specifically one called enkephalin. This small peptide plays big roles: from reducing stress responses to enhancing cognitive functions [1].

Research indicates that Selank might also influence serotonin and dopamine – two neurotransmitters responsible for feelings of happiness and pleasure [4]. 

Experimental Applications of Selank

The scientific community has been intrigued by the potential uses of Selank peptide. Its versatility as a research chemical is being tested across various experimental settings.

Generalized Anxiety Disorder and Stress Management

GABA – Gamma-aminobutyric acid is a neurotransmitter that helps control fear and reduce anxiety by inhibiting certain brain signals [5].

There’s evidence that Selank might have an effect on gene expression of GABA receptors. It’s thought that Selank may influence GABAergic activity, potentially giving rise to its anti-anxiety effects and curving generalized anxiety disorders [5].

Cognitive Enhancement

There’s also interest in Selank’s possible cognitive benefits. A number of studies suggest this peptide may boost learning capacity or memory retention. In fact, an article demonstrated improved spatial memory and learning processes among rodents administered with Selank [6].

Immune System Regulation and Improved Immune Function

Selank could potentially play a role in immune system function too. Researchers have noticed changes in cytokine levels following administration which suggests immunomodulatory properties [7].

Comparing Selank with Similar Peptides

Peptide research is an evolving field, and Selank has garnered attention for its unique properties. Let’s take a comparative look at Selank and similar peptides such as Semax and BPC-157.

Selank vs. Semax

Semax is another peptide of Russian origin like Selank. While both have shown potential to influence cognitive functions, their mechanisms are distinctively different [8].

Semax works by stimulating nerve growth factor (NGF) production which influences neuronal survival and differentiation. On the other hand, Selank seems to modulate the expression of certain genes involved in immune response regulation [8].

Selank vs. BPC-157

BPC-157 is a body protection compound that shows promise in tissue healing processes while also possessing anti-inflammatory effects. Unlike Selank which acts on the nervous system primarily, BPC-157 targets damaged tissues directly to promote recovery. Studies show BPC-157 helps restore tendons, ligaments, brain tissue amongst others [9].

  • All three peptides hold great promise but each follows its own pathway towards potential benefits.
  • The choice between them depends on what researchers aim to study or achieve through experimentation.
  • A comprehensive understanding of these differences can help scientists choose appropriately for specific applications.

Selank Attenuates Aversive Signs of Morphine

In a study involving outbred rats utilizing the naloxone-precipitated morphine withdrawal model, the efficacy of a peptide tuftsin analog Selank was examined. Administered intraperitoneally at an anxiolytic dosage of 0.3 mg/kg, Selank exhibited a notable reduction of 39.6% in the overall index of morphine withdrawal syndrome [10]. 

It significantly mitigated convulsive reactions, ptosis, and posture irregularities, while elevating the tactile sensitivity threshold by 9-fold in morphine-dependent rats compared to the active control group [10].  

Although slightly less potent than diazepam (2 mg/kg), which displayed a 49.3% reduction in the total index and a 13-fold sensitivity threshold increase, Selank demonstrated the capacity to ameliorate the adverse manifestations of morphine withdrawal in rats with opiate dependence, akin to the effects of diazepam [10]. 

Legal and Regulatory Status of Selank

The legal status of the Selank peptide can vary significantly depending on geographical location. Some regions have specific regulations, while others leave it in a sort of gray area.

In the United States, for instance, peptides like Selank are not regulated by the Food and Drug Administration (FDA) for personal use. They’re categorized as research chemicals which means they’re only meant to be used in laboratories or clinical studies but not intended for human consumption.

Similarly, Australia’s Therapeutic Goods Administration doesn’t consider Selank a controlled substance either, but similarly restricts its use to scientific research contexts. But again stresses their role strictly within scientific research contexts.

In contrast to these two examples, Russia recognizes some therapeutic uses of Selank and has approved it under certain conditions since 2009.

Purchasing from Trusted Suppliers

If you need this compound for your research work then getting high-quality compounds is crucial because impurities can skew results or even lead to false conclusions. provides third-party testing results along with an up-to-date Certificate Of Analysis (COA). These COAs help verify both purity levels and authenticity ensuring quality control.

Beware Fake Products

Sadly though counterfeit products exist out there that might look real but aren’t effective due to poor manufacturing practices or substandard ingredients used during the synthesis process leading to loss of efficacy.

FAQs About Selank Peptide

Selank peptide, as a research chemical, shows promise in the study of anxiety disorders due to its potential anxiolytic properties [2].

Selank may influence certain neurotransmitters in the brain that modulate mood and cognition according to some scientific findings. More research is needed though [2].

Selank appears to inhibit the release of stress-related neurotransmitters like serotonin, which contributes to its anxiolytic effects and potential to decrease negative cognitive and emotional symptoms associated with anxiety disorders [4]. 

The primary benefit observed in studies with Selank is its possible stress-reducing and cognitive enhancing effects. However, it’s still under investigation [2,4].


Developed at the Russian Academy of Sciences, Selank peptide offers a promising avenue to reduce anxiety, cognitive enhancement, improved immune function, and easing morphine dependency. While more research is needed to fully understand its mechanisms and long-term effects, Selank remains an intriguing peptide with potential applications in mental health and cognitive well-being [2]. 

 Always consult a healthcare professional for personalized guidance and treatment options. Visit our database of reliable doctors for more information on peptides. 

Scientific Research References:

1. min T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014 Mar;58(1):50-5. doi: 10.1016/j.molimm.2013.11.002. Epub 2013 Nov 27. PMID: 24291245.

2. Koroleva, S. V., & Mjasoedov, N. F. (2019). Physiological effects of Selank and its fragments. Biology Bulletin, 46(4), 407-414.

4. Nadorova, A. V., Kolik, L. G., Klodt, P. M., Narkevich, V. B., Naplyokova, P. L., Kozlovskaya, M. M., & Kudrin, V. S. (2014). The relationship between the anxiolytic action of selank and the level of serotonin in brain structures during the modeling of alcohol abstinence in rats. Neurochemical journal, 8, 115-120.

5. Vyunova, T. V., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity. Protein and Peptide Letters, 25(10), 914-923.

6. Kolik, L. G., Nadorova, A. V., Antipova, T. A., Kruglov, S. V., Kudrin, V. S., & Durnev, A. D. (2019). Selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. Bulletin of Experimental Biology and Medicine, 167(5), 641-644.

7. Kolomin, T., Morozova, M., Volkova, A., Shadrina, M., Andreeva, L., Slominsky, P., Limborska, S., & Myasoedov, N. (2014). The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Molecular Immunology, 58(1), 50-55. 

8. Panikratova, Y. R., Lebedeva, I. S., Sokolov, O. Y., Rumshiskaya, A. D., Kupriyanov, D. A., Kost, N. V., & Myasoedov, N. F. (2020, January). Functional connectomic approach to studying selank and semax effects. In Doklady Biological Sciences (Vol. 490, pp. 9-11). Pleiades Publishing.

9. Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … & Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology-Paris, 91(3-5), 173-178.

10. Konstantinopolsky, M. A., Chernyakova, I. V., & Kolik, L. G. (2022). Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bulletin of Experimental Biology and Medicine, 173(6), 730-733.

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