What is Epithalon?
The Epithalon Peptide, also known as Epitalon or Epithalamin, is a synthetic tetrapeptide composed of four amino acids: Ala-Glu-Asp-Gly. It was originally derived from Epithalamin, a naturally occurring peptide secreted by the pineal gland.
Scientific studies have explored Epithalon’s role in aging research, telomerase activation, and circadian rhythm regulation. It has been studied for its potential to promote cellular longevity, regulate melatonin levels, and reduce oxidative stress in research models.
Epithalon and Telomere Research
Telomeres and Cellular Aging
Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. Telomere shortening is linked to cellular aging and senescence.
Research suggests that Epithalon may:
✔️ Activate telomerase, the enzyme responsible for maintaining telomeres.
✔️ Extend cellular lifespan in laboratory models.
✔️ Improve DNA repair mechanisms, potentially reducing age-related decline.
Scientific Studies on Epithalon and Longevity
- A study published in Biogerontology (2010) examined the impact of Epithalon on human fibroblast cells. Results indicated that cells treated with Epithalon showed increased telomerase activity and a prolonged lifespan compared to control cells. (Biogerontology, 2010)
- Animal studies have demonstrated that Epithalon administration increased lifespan and improved physiological functions in aged rats.
These findings suggest that Epithalon may have potential implications for aging and longevity research, though further studies are needed.
Epithalon and Melatonin Regulation
Melatonin is a hormone responsible for regulating sleep cycles, circadian rhythms, and oxidative stress. The pineal gland’s ability to produce melatonin declines with age, leading to disruptions in sleep and metabolic regulation.
Studies indicate that Epithalon may:
âś… Stimulate melatonin secretion, improving sleep quality.
âś… Help regulate circadian rhythms in aging models.
âś… Support antioxidant defense mechanisms by reducing oxidative stress.
Potential Research Benefits of Epithalon
| Research Area | Potential Findings |
|---|---|
| Longevity Studies | May extend cell lifespan via telomerase activation. |
| Sleep & Circadian Rhythm | May regulate melatonin production for better sleep. |
| Immune System Support | May enhance immune function in aging models. |
| Antioxidant Properties | May reduce oxidative stress and DNA damage. |
While promising, Epithalon is strictly for research use and not approved for human or veterinary applications.
Product Specifications for Research Use
- CAS Number: 307297-39-8
- Chemical Formula: C14H22N4O9
- Sequence: Ala-Glu-Asp-Gly
- Molar Mass: 390.35 g/mol
- Purity: Minimum 98%
- Storage: Keep refrigerated upon reconstitution.
Research Material Information:
✔️ Lyophilized sample in a sterile glass vial
✔️ 5 mg Epithalon per vial
✔️ Diluent and laboratory supplies not included
For Research Use Only
This preparation is strictly for laboratory research purposes by qualified professionals. Epithalon is not a drug, food, supplement, or cosmetic and should not be misbranded, misused, or mislabeled as such.
đź“Ś Note: Epithalon has not been evaluated by regulatory authorities and is not intended for human or veterinary use.
FAQs: Epithalon Peptide Research
The Epithalon peptide is studied for telomerase activation, aging research, and melatonin regulation in laboratory models.
Research suggests that Epithalon may stimulate telomerase, supporting DNA repair and cellular longevity.
No. Epithalon is strictly for research purposes and has not been approved by the FDA for human or veterinary applications.
Epithalon is reconstituted and used in controlled laboratory experiments on cell cultures and research models.
Conclusion
Epithalon peptide has been widely studied for its potential role in telomere maintenance, cellular longevity, and sleep regulation. Scientific research suggests that it may activate telomerase, improve melatonin levels, and enhance antioxidant defense in research models.
However, Epithalon is strictly for laboratory research purposes and has not been approved for human use. Ongoing studies continue to explore its full range of biological functions in aging and longevity research.
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Resources
1. Anisimov, V. N., & Khavinson, V. K. (2010). Peptide bioregulation of aging: results and prospects. Biogerontology, 11(2), 139-149.
2. Khavinson, V., Linkova, N., Dyatlova, A., Kuznik, B., & Umnov, R. (2020). Peptides: prospects for use in the treatment of COVID-19. Molecules, 25(19), 4389.
3. Avolio, F., Martinotti, S., Khavinson, V. K., Esposito, J. E., Giambuzzi, G., Marino, A., … & Toniato, E. (2022). Peptides regulating proliferative activity and inflammatory pathways in the monocyte/macrophage THP-1 cell line. International Journal of Molecular Sciences, 23(7), 3607.
4. Sinjari, B., Diomede, F., Khavinson, V., Mironova, E., Linkova, N., Trofimova, S., … & Caputi, S. (2020). Short peptides protect oral stem cells from ageing. Stem cell reviews and reports, 16, 159-166.
5. Khavinson, V., & Popovich, I. (2017). Short peptides regulate gene expression, protein synthesis and enhance life span.
6. Vanyushin, B. F., & Khavinson, V. K. (2016). Short biologically active peptides as epigenetic modulators of gene activity. Epigenetics-A Different Way of Looking at Genetics, 69-90.
7. Knufinke, M., MacArthur, M. R., Ewald, C. Y., & Mitchell, S. J. (2023). Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review. Frontiers in Aging, 4, 1172789.
8. Lezhava, T., Jokhadze, T., Monaselidze, J., Buadze, T., Gaiozishvili, M., Sigua, T., … & Kilaberia, E. (2022). Epigenetic Variations in Chromatin Caused by the Combination of Bioregulators with Heavy Metals During Aging. International Journal of Peptide Research and Therapeutics, 28(4), 121.
